Abstract
A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 157 (4'-chloro), 158 (4'-bromo), and 182 (5-chloro, 4'-bromo) were more potent than indomethacin in these assays.
MeSH terms
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Analgesia
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Animals
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Anti-Inflammatory Agents / chemical synthesis*
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Arthritis, Experimental / drug therapy
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Chemical Phenomena
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Chemistry
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Cyclooxygenase Inhibitors
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Female
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Indomethacin / therapeutic use
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Intestines / drug effects
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Isomerism
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Male
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Phenylacetates / chemical synthesis*
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Phenylacetates / therapeutic use
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Phenylacetates / toxicity
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Rats
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Rats, Inbred Strains
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Stomach / drug effects
Substances
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Anti-Inflammatory Agents
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Cyclooxygenase Inhibitors
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Phenylacetates
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amfenac
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Indomethacin